Research Assistant
Phone
+41 61 267 02 79
Angela Heck
Division of Molecular Neuroscience
University of Basel
Birmannsgasse 8
CH-4009 Basel, Switzerland

Publications

  • 1: Heck A, Fastenrath M, Ackermann S, Auschra B, Bickel H, Coynel D, Gschwind L, Jessen F, Kaduszkiewicz H, Maier W, Milnik A, Pentzek M, Riedel-Heller SG, Ripke S, Spalek K, Sullivan P, Vogler C, Wagner M, Weyerer S, Wolfsgruber S, de Quervain DJ, Papassotiropoulos A. Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity. Neuron. 2014 Mar 5;81(5):1203-13. doi: 10.1016/j.neuron.2014.01.010. Epub 2014 Feb 13. PubMed PMID: 24529980; PubMed Central PMCID: PMC4205276.
  • 2: Heck A, Lieb R, Unschuld PG, Ellgas A, Pfister H, Lucae S, Erhardt A, Himmerich H, Horstmann S, Kloiber S, Ripke S, Müller-Myhsok B, Bettecken T, Uhr M, Holsboer F, Ising M. Evidence for associations between PDE4D polymorphisms and a subtype of neuroticism. Mol Psychiatry. 2008 Sep;13(9):831-2. doi: 10.1038/mp.2008.2. PubMed PMID: 18711446.
  • 3: Heck A, Vogler C, Gschwind L, Ackermann S, Auschra B, Spalek K, Rasch B, de Quervain D, Papassotiropoulos A. Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory. PLoS One. 2011;6(12):e29337. doi: 10.1371/journal.pone.0029337. Epub 2011 Dec 21. PubMed PMID: 22216252; PubMed Central PMCID: PMC3244442.
  • 4: Heck A, Lieb R, Ellgas A, Pfister H, Lucae S, Erhardt A, Himmerich H, Horstmann S, Kloiber S, Ripke S, Müller-Myhsok B, Bettecken T, Uhr M, Holsboer F, Ising M. Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients. Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):104-14. doi: 10.1002/ajmg.b.30784. PubMed PMID: 18484085.
  • 5: Heck A, Lieb R, Ellgas A, Pfister H, Lucae S, Erhardt A, Himmerich H, Horstmann S, Kloiber S, Ripke S, Müller-Myhsok B, Bettecken T, Uhr M, Holsboer F, Ising M. Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients. Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):104-14. doi: 10.1002/ajmg.b.30784. PubMed PMID: 18484085.
  • 6: Heck A, Pfister H, Czamara D, Müller-Myhsok B, Pütz B, Lucae S, Hennings J, Ising M. Evidence for associations between MDGA2 polymorphisms and harm avoidance: replication and extension of a genome-wide association finding. Psychiatr Genet. 2011 Oct;21(5):257-60. doi: 10.1097/YPG.0b013e3283457bfb. PubMed PMID: 21399569.
  • 7: Ising M, Mather KA, Zimmermann P, Brückl T, Höhne N, Heck A, Schenk LA, Rujescu D, Armstrong NJ, Sachdev PS, Reppermund S. Genetic effects on information processing speed are moderated by age - converging results from three samples. Genes Brain Behav. 2014 Mar 14. doi: 10.1111/gbb.12132. [Epub ahead of print] PubMed PMID: 24629169.
  • 8: de Quervain DJ, Kolassa IT, Ackermann S, Aerni A, Boesiger P, Demougin P, Elbert T, Ertl V, Gschwind L, Hadziselimovic N, Hanser E, Heck A, Hieber P, Huynh KD, Klarhöfer M, Luechinger R, Rasch B, Scheffler K, Spalek K, Stippich C, Vogler C, Vukojevic V, Stetak A, Papassotiropoulos A. PKCα is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8746-51. doi: 10.1073/pnas.1200857109. Epub 2012 May 14. PubMed PMID: 22586106; PubMed Central PMCID: PMC3365172.
  • 9: Klengel T, Heck A, Pfister H, Brückl T, Hennings JM, Menke A, Czamara D, Müller-Myhsok B, Ising M. Somatization in major depression--clinical features and genetic associations. Acta Psychiatr Scand. 2011 Oct;124(4):317-28. doi: 10.1111/j.1600-0447.2011.01743.x. Epub 2011 Aug 13. PubMed PMID: 21838737.
  • 10: Quast C, Altmann A, Weber P, Arloth J, Bader D, Heck A, Pfister H, Müller-Myhsok B, Erhardt A, Binder EB. Rare variants in TMEM132D in a case-control sample for panic disorder. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec;159B(8):896-907. doi: 10.1002/ajmg.b.32096. Epub 2012 Aug 22. PubMed PMID: 22911938.
  • 11: Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld PG, Ripke S, Specht M, Kohli MA, Kloiber S, Ising M, Heck A, Pfister H, Zimmermann P, Lieb R, Pütz B, Uhr M, Weber P, Deussing JM, Gonik M, Bunck M, Kebler MS, Frank E, Hohoff C, Domschke K, Krakowitzky P, Maier W, Bandelow B, Jacob C, Deckert J, Schreiber S, Strohmaier J, Nöthen M, Cichon S, Rietschel M, Bettecken T, Keck ME, Landgraf R, Müller-Myhsok B, Holsboer F, Binder EB. TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. Mol Psychiatry. 2011 Jun;16(6):647-63. doi: 10.1038/mp.2010.41. Epub 2010 Apr 6. PubMed PMID: 20368705.
  • 12: Papassotiropoulos A, Gerhards C, Heck A, Ackermann S, Aerni A, Schicktanz N, Auschra B, Demougin P, Mumme E, Elbert T, Ertl V, Gschwind L, Hanser E, Huynh KD, Jessen F, Kolassa IT, Milnik A, Paganetti P, Spalek K, Vogler C, Muhs A, Pfeifer A, de Quervain DJ. Human genome-guided identification of memory-modulating drugs. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4369-74. doi: 10.1073/pnas.1314478110. Epub 2013 Oct 21. PubMed PMID: 24145423; PubMed Central PMCID: PMC3831994.
  • 13: Ackermann S, Heck A, Rasch B, Papassotiropoulos A, de Quervain DJ. The BclI polymorphism of the glucocorticoid receptor gene is associated with emotional memory performance in healthy individuals. Psychoneuroendocrinology. 2013 Jul;38(7):1203-7. doi: 10.1016/j.psyneuen.2012.10.009. Epub 2012 Nov 10. PubMed PMID: 23148886.
  • 14: Hennings JM, Kohli MA, Czamara D, Giese M, Eckert A, Wolf C, Heck A, Domschke K, Arolt V, Baune BT, Horstmann S, Brückl T, Klengel T, Menke A, Müller-Myhsok B, Ising M, Uhr M, Lucae S. Possible associations of NTRK2 polymorphisms with antidepressant treatment outcome: findings from an extended tag SNP approach. PLoS One. 2013 Jun 4;8(6):e64947. doi: 10.1371/journal.pone.0064947. Print 2013. PubMed PMID: 23750220; PubMed Central PMCID: PMC3672143.
  • 15: Vukojevic V, Kolassa IT, Fastenrath M, Gschwind L, Spalek K, Milnik A, Heck A, Vogler C, Wilker S, Demougin P, Peter F, Atucha E, Stetak A, Roozendaal B, Elbert T, Papassotiropoulos A, de Quervain DJ. Epigenetic modification of the glucocorticoid receptor gene is linked to traumatic memory and post-traumatic stress disorder risk in genocide survivors. J Neurosci. 2014 Jul 30;34(31):10274-84. doi: 10.1523/JNEUROSCI.1526-14.2014. PubMed PMID: 25080589.
  • 16: Luksys G, Ackermann S, Coynel D, Fastenrath M, Gschwind L, Heck A, Rasch B, Spalek K, Vogler C, Papassotiropoulos A, de Quervain D. BAIAP2 is related to emotional modulation of human memory strength. PLoS One. 2014 Jan 2;9(1):e83707. doi: 10.1371/journal.pone.0083707. eCollection 2014. Erratum in: PLoS One. 2014;9(3):e92933. PubMed PMID: 24392092; PubMed Central PMCID: PMC3879265.
  • 17: Milnik A, Heck A, Vogler C, Heinze HJ, de Quervain DJ, Papassotiropoulos A. Association of KIBRA with episodic and working memory: a meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec;159B(8):958-69. doi: 10.1002/ajmg.b.32101. Epub 2012 Oct 12. PubMed PMID: 23065961.
  • 18: Fulda S, Szesny N, Ising M, Heck A, Grübl A, Lieb R, Reppermund S. Further evidence for executive dysfunction in subjects with RLS from a non-clinical sample. Sleep Med. 2011 Dec;12(10):1003-7. doi: 10.1016/j.sleep.2011.04.013. Epub 2011 Oct 14. PubMed PMID: 22000419.
  • 19: Unschuld PG, Ising M, Specht M, Erhardt A, Ripke S, Heck A, Kloiber S, Straub V, Brueckl T, Müller-Myhsok B, Holsboer F, Binder EB. Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders. Am J Med Genet B Neuropsychiatr Genet. 2009 Dec 5;150B(8):1100-9. doi: 10.1002/ajmg.b.30938. PubMed PMID: 19229853.
  • 20: Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB. The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron. 2011 Apr 28;70(2):252-65. doi: 10.1016/j.neuron.2011.04.005. PubMed PMID: 21521612; PubMed Central PMCID: PMC3112053.